Fatty Meals May Impair Artery Function

Fatty Meals May Impair Artery Function


“Fatty Meals May Impair Artery Function” The phenomenon of postprandial angina
was described over 200 years ago: chest pain that occurs after a meal, even
if you’re just sitting down and resting. The question is why? It could be intuitively attributed
to redistribution of blood flow away from the heart to
the gut during digestion, however such a mechanism could
not be demonstrated experimentally. We now know the problem appears to be
within the coronary arteries themselves. The clue came in 1955, when researchers
found that they could induce angina in people with heart disease
just by having them drink fat. This is what was happening in their
bloodstream in the 6 hours after the meal. This is a graph of so-called lactescence,
which means milkiness. Their blood became increasingly milky
with fat over the next five hours. And each of the ten attacks of
angina was found to occur about four and a half to five
hours after the fatty meal, right when blood milkiness
was at or near its peak. Here’s the curve after a nonfat meal. Same bulk and calories, but made out
of starch, sugar, and protein. And no anginal pain was elicited in
any of the patients they tested after the ingestion of the nonfat meal. How could just the presence of fat in
the blood affect blood flow to the heart? To understand that we need
to understand the endothelium, the inner lining of all
of our blood vessels. Our arteries are not just rigid pipes. They are living breathing organs
that actively dilate or constrict, depending on what’s needed. They thin or thicken the blood,
release hormones. And it’s all controlled by the single
inner layer, the endothelium, making it the body’s largest
endocrine organ, the largest hormone-secreting organ, weighing a total of three
pounds all gathered up, with a combined surface
area of 700 square yards. We used to think the endothelium
was just an inert layer lining our vascular tree,
but now we know better. The endothelium is directly involved
in peripheral vascular disease, stroke, heart disease, diabetes, insulin resistance,
chronic kidney failure, tumor growth, metastasis, venous thrombosis (blood
clots), and severe viral infectious diseases. Dysfunction of the vascular endothelium
is thus a hallmark of human diseases. Researchers found that low fat meals
tended to improve endothelial function, and high fat meals tended to
worsen endothelial function. And this goes for animal fat, as
well as for isolated plant fats, sunflower oil in this case. But maybe it’s just the digestion
of fat rather than the fat itself? Our body can detect the presence
of fat in the digestive tract, and releases a special group of hormones
and enzymes to deal with it. So researchers tried feeding
people fake fat. The real fat deprived the heart
of blood; the fake fat didn’t. But maybe our body is smart
enough to know the difference? This is the study that really nailed it. They tried infusing fat directly into
people’s bloodstream through an IV, so your brain doesn’t know
if you’re eating fat or not. And indeed, within hours
their arteries became stiffened, significantly crippling their ability
to relax and dilate normally. This decrease in the ability to vasodilate
coronary arteries after a fatty meal just when you need it could explain
the phenomenon of after-meal angina in patients with known
coronary artery disease.

48 thoughts on “Fatty Meals May Impair Artery Function

  1. If plant based diet will help to lower risk of most common causes of death, what are the leading causes of death for vegans? Are there any statistics on that?

  2. interested to hear if nuts, avodaoes, flax, nut butters, etc., also have the same effect on the blood and arteries as oils and lards.

  3. wer immer noch nicht glaubt, dass öl schädlich für unseren körper ist, schaut sich mal diese studienzusammenfassung an:
    thanks to dr greger!!!

  4. aaaah i love being a superior human being and not a typical stupid fat chronic disease loving american.  being a vegan is so amazing.  YAY VEGANS!!!  HEEHEHEEHEHEHEEE!!!

  5. If high fat along with animal protein and other substances like roasted flavors i.e. AGEs are so deleterious to health, why are we sensitized to them, why do we crave them? It's just all too cruel.

  6. I try to get at least 75 grams of fat each day. One needs that for max T production. It's actually not that easy. Not enough fat, and estrogen takes over, and one gets fat.

  7. Dr. Greger failed to mention that Canola oil and Salmon oil don't have the same negative effect as even the great and touted heart-healthy olive oil.

  8. I'm curious, is there anyone following a whole-foods plant-based diet for long enough to see the benefit who feels compelled to troll Paleo diet websites and spew nonsense? I can't imagine anyone wasting that much time . . . unless they have a financial interest or an eating disorder.

  9. Let's say you add two tablespoons of cold pressed avocado oil to your medley of vegetables and whole grain rice, millet, or quinoa after everything is prepared so as not to damage the oil from heat, would that be harmful?

  10. I have a chronic illness/disease that affects the dilation of my arteries when changing positions from lying, to sitting, then from sitting to standing. Essentially blood pools into the calfs of my legs and because there's no dilation it doesn't constrict my blood pressure from droppping, therefore it doesn't reach the brain,  I'll then obtain tachycardia (fast heart rate) to compensate. In the mean time I'll go woozy have a spaz fit.

    I think I've damaged my body from never eatinghealthy food, lacking nutrients, and not exercising. :/
    society with its addicting processed foods and animal products and ill information is the reason I have such a restrictive life with a shitty chronic illness.

  11. As predicted, the know-it-all fucknut appears with his "cutting edge" science that he retrieved from Google.

    Bravo for being pseudo-intellectual.

  12. Complete nonsense! There is no evidence that saturated fat causes heart disease whatsoever! 

    Since the 1970s when low-fat diets were promoted, obesity rates have skyrocketed from just 2% to a whopping 25% of the population!

    Why would I choose margarine, which is a slew of chemicals and is grey before it's dyed yellow, over natural butter containing only cream and salt?

  13. Why is heart disease still the No. 1 killer in America if the low-fat dietary advice pushed since the 1970s is right?

  14. I was starting to get heart pain during my high fat vegan diet experiment a few months ago.  I was consuming nuts and seeds, avocados, and coconut, olive and flax oil for the bulk of my calories, along with tons of vegetables and some low sugar fruits.  It wasn't working at all.  Was getting arthritis, and other terrible symptoms that all went away when I went back to high carb.

  15. I've been vegan for a few years now and maybe it's just me, but I've become so sensitive to my body that every once in a while when I do eat butter or cream or egg yolks I can almost feel it in my heart the fat clogging in my artery, LOL

  16. Help me understand what morons click dislike on this video when they can even spell endothelium without autocorrect helping. Seriously. What's to dislike??

  17. hello dr greger,
    can you please do a video on that study?
    http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0088278
    it supposedly shows,that vegetarians are unhealthier

  18. Inject fat via IV? Is that how we eat fat? Or just to win the argument no matter how absurd is the experiment? I am not a doctor, common sense, which every human are born with, tells me something fishy going on here.

  19. For more info on this, read up on Dr. Roy Swank, who began to research this topic more than 50 years ago, even though he didn't have the means for such in depth findings then, of course.

  20. Aha I just don't have the time for this, FAT DOESN'T CAUSE HEART DISEASE. For fuck sake. Instead of telling people to avoid a vital component in their diet tell them what they can actually do to help there heart. It is ironic that these fats and cholesterol are so demonized since they are so vital for heart and arterial integrity. The bodies inability to heal and maintain these components are the reason they are failing.
    Vitamin C is certainly the most important factor, I honestly think if everyone in the Western world took 2grams of Vitamin C a day (assuming they have enough copper) almost no one would get heart disease. There are other factors too like Low selenium can induce a weak heart etc. But Vitamin C is the single most potent thing anyone can do to help there heart.

  21. Anyone with any thoughts on algae-based DHA as an "isolated plant fat" affecting arteries? I wonder of there's a certain threshold for it to exert an effect bc it's a minute amount

  22. Fatty meals MAY impair artery function, but they DON"T. Insulin resistance is killing more Americans every decade, yet you keep urging people to eat a low-fat (high-carb) diet. That's what gives us obesity, cardiovascular disease, diabetes, hypertension, and a whole rogues gallery of ghastly diseases that you physicians can only shake their heads at and offer not cure for. It's the diet, stupid!

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