Priming the proton pump

Priming the proton pump


Priming the Proton Pump What could possibly
be in beet juice to so revolutionize the field
of sports physiology? First, a quick biochemistry breather. Our body uses oxygen to create ATP,
the energy currency of our bodies. Every time we think;
every time we blink; every time we flex a muscle;
we use up ATP, which has to be replenished by
breathing more oxygen—or we die. The enzyme that makes ATP
(ATP synthase), deep inside our cells, is literally a microscopic
rotary mechanical motor. Oxygen causes the flow of protons,
and like a water wheel in that flow, the enzyme turns,
and makes ATP. Like any motor, it’s not perfectly efficient. There’s some slippage of the gears. There’s proton leakage out the edges. But it’s an extraordinary mechanism. Okay, so where do beets come in? Well, beets offer one of the most
concentrated sources of dietary nitrate, which is absorbed in our stomach,
and then actively concentrated and pumped back into our mouth
through our salivary glands, because our body knows that there
are special commensal bacteria that live on our tongue. Our tongue bacteria take these nitrates,
and convert them into nitrites, which are then re-swallowed,
absorbed again, and then make their way to our cells, and then
converted into a third compound— nitric oxide, which then
acts on the proton pump to either reduce the slippage,
or plug up the leaks, or even take the place of oxygen
in the whole contraption. We’re still not sure,
but this is why they think beets are able to reduce
the oxygen cost of exercise, while improving athletic performance.

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